Silkworth is currently my favorite professor in the biochemistry department. Between 153A and 153C, I would say that I enjoyed 153B the most. However, there is SOOOOO much material that's taught in this course. It literally takes the central dogma (DNA --> RNA ---> Proteins) and tells you EVERYTHING about it.

The trick to doing well in this course is very simple: Answer all the "what you should know" questions slides in the powerpoint. Do that, and ur pretty much golden for the exams. you don't need to attend any office hours (I didn't even once) or redo the clicker questions. And the best way to answer those "what you should know" questions is to record each lecture on your phone. After class, re-listen to the lectures, and use the recordings to answer the "what you should know" questions. I knew from previous students that this course was going to be hard, so I prepared myself. Going to tutorial also helps as well, cause silkworth dumbs the concepts down in tutorial. Make sure not to lose points over dumb things, like not attending discussion, or not taking the CCLE quizzes seriously (the answers to the CCLE quizzes are from lecture btw), or not doing the clickers.

Don't think you can study all the material for this class 2 days before the exam. It ain't happening. Study the slides a bit each day (literally no more than 1 hour), and you will be fine. The average for both midterms was around 75%; for the exams, you will definitely need the whole time length, so be ready in that regard. I'm pretty sure this class is curved to having the average be a B/B+, so don't worry too much about it. Good luck to you all

Silkworth is a decent lecturer; he basically teaches off of powerpoint slides and does not expect students to know something way beyond the scope of the course. He definitely cares a lot about student learning, and is willing to answer questions multiple times if students are confused. His tutorial sections are run as group office hours, in that he basically opens up the class to ask him any questions they have. Parts of this can be useful, but honestly, I found that half of the time I did not really pay attention because either (1) I was behind in studying and couldn't understand the topics discussed or (2) the topics discussed were beyond the scope of the course.
The exams are pretty fair, but beware that the two midterms can be time crunches as there were about 6 questions to finish in 50 mins. The final was definitely harder, but still reasonable, and he pushed us to apply concepts in new and original questions. Before each exam, he will give a list of exam review topics to study - focus on these as opposed to trying to do problem sets/memorizing everything/etc.
In terms of material, I honestly did not enjoy it too much because I enjoy chem more than bio, but this class is great for those who love the central dogma, as you go in great depths learning about DNA and RNA.
Also, Silkworth states in the syllabus that he grades according to an adjusted straight scale (i.e. A- is set at 88-92%); I'm pretty sure he ended up curving though, so don't worry too much about your grade.
In summary, Silkworth's a decent lecturer, but sometimes you'll have to ask him a few times to repeat things because it might not have been explained clearly at first.