Going to give you the most honest review here. I never read the lab manual or watched the online lectures for this class. For the quizzes, I relied solely on the quizlet. There are quizlets out there that have ALL of the pre-lab and in-lab quiz questions in them. The post-lab questions are a bit harder to get, but if you can get your hands on the LS 23L Final Question Bank, it's basically questions taken from there. The final exam consists of probably around 50% of questions taken from the past 23L Final questions in the Question Bank. The questions are very similar to the post-lab quizzes.
In lab, I basically went through the motions. I didn't know what the heck I was doing or why I was doing it. I just followed the instructions. To get full credit on the in-lab assignments, ask your UA questions!! They will help you!
As for the lab reports, use past labs as a guideline. The TAs will take off points for the dumbest of things! You'll see what I'm talking about after you get your 1st or 2nd lab report back. Basically, do not write in third person, do not include anything in the results section other than results (DO NOT EXPLAIN ANYTHING IN THIS SECTION, you will get points taken off!!), always include your null and alternative hypothesis, go in depth in the conclusion (talk about how you could make the experiment better, where the experiment went wrong, etc). Also, always include units to back up your numbers!!

Grading Scheme:
Pre-lab quizzes - 6 points each x 9 = 54 points (-6 points from lowest score)
In-lab quizzes - 7 points each x 10 = 70 points (-7 points from lowest score)
Post-lab quizzes - 2 points each x 10 = 20 points (-2 points from lowest score)
Assignments - 259 points total (10 assignments)
Lab participation - 6 points
Evaluations - 6 points
Final - 100 points
Total - 500 points

Professor Pfuegl:
I never actually met Pfluegl in person because this class consists of watching videos with Pfluegl narrating and going to one 3-hour lab a week. The lab manual is basically mandatory. It'd be wise to get the new copy (4th edition) because it contains different material from the previous one. I heard rumors that he's a pretty big stickler for keeping everyone in lab for the whole 3-hours even if you're finished early, so that can be a bit of a drag. Otherwise, to be honest, the lecture videos are not really worth watching. You never get tested on the material covered. The essential stuff to know is in the lab manual. The videos just kind of give a wider scope and background of the week's lab. Even though I did watch them and take notes on them, you could probably do well in this class without even watching them at all.

TA Sara Ranjbarvaziri:
Sara was pretty nice in labs. Labs overall seemed really dragged out and involved a lot of waiting. Some of the labs could probably be condensed to half the time if they really tried. However, Sara was a really easy grader for lab reports. In the last report though, she graded a bit tougher because she got in trouble with Pfluegl for grading too easily. She's not strict about cell phone usage, but she is pretty stern about paying attention when it's important.

Pre-lab quizzes grade: 48/48
So before each lab you have to complete an online quiz on CCLE that contains a few multiple choice questions about the lab. These are really simple and they give you 20 minutes to complete. I just usually skimmed the manual for key words in the question without actually reading the lab.

In-lab quizzes grade: 61/63
These are pretty much the same deal as the pre-lab quizzes, except they're done on paper at the beginning of each lab. Sometimes the same questions pop up. I just quickly read through the lab manual right before labs. You get about 10-15 minutes to complete them, but it doesn't take that long.

Post-lab quizzes grade: 17.5/18
The post-lab quizzes sometimes make you recall things you did in lab, but you can usually just rely on the lab manual again to answer the questions on CCLE. They give you an hour for these quizzes, but again, it's too much time.

Assignments grade: 249.75/259
So most of these points were from in-lab worksheets you completed as you did the labs. These were pretty simple. Just got knocked off a point here and there. Another big part of the points for the assignments grade was 3 lab reports and a proposal. The first one was kind of a trail run and not worth a lot of points. I got 13.25/14 on it. The second one was worth more, and I got 39.5/40. At this point my TA was told to grade harder, so for the last lab report I got 36.5/40 and for the proposal I got 8/10. Sara basically graded our reports kind of like a checklist. If you included everything you should have, you got credit for it. They're pretty simple to write, but you get a week to complete each report, and the last report was tied in with the proposal, so you have to plan out how to complete them within the time frame accordingly.

Lab participation grade: 6/6
This basically involved just signing up for a question related to the next week's lab during the lab in the previous week. Then on the day of the lab when it was your turn you just gave a 30-second blurb. Sara graded it just that if you did it you got full credit. Really easy. Usually the questions can be answered just from reading the lab manual or watching a lecture video.

Evaluations grade: 6/6
You had to evaluate Professor Pfluegl, your TA, and your two UAs (undergraduate assistants who helped facilitate labs with the TA) to get full credit.

Final grade: 80%
The final was really really simple. It was 40 multiple choice questions that were similar in style to the post-lab quizzes. I recommend just going through the lab manual a couple time and the post-lab quizzes to study. That's all you need. They also gave a practice exam of the same fashion which was somewhat helpful. You schedule an hour to take the exam in the computer lab during finals week. But it really only takes 15-20 minutes to complete.

Overall grade: A
This class was really simple. Not a lot of work and easy assignments. Not difficult to take concurrently with LS 4. I recommend taking this class with Pfluegl.

Although students meet in person with the TA for the lab portion of this course, the lectures are posted online on a separate website. The lectures weren't entirely necessary for my overall understanding of the class, but they gave me a good idea of what to expect for the labs that week, and they were only about 30 minutes each. Despite taking this class during the summer, the workload was very light and manageable. Although the lab reports themselves, which we had 3 to complete, were time-consuming, my TA was very helpful and willing to answer all the questions I had. Once you get through the first lab report, you find the right methods to approach the other 2 reports and the process becomes easier. There were worksheets, but we were able to work on them in class with our lab group members, and we turned them in before leaving the class. This class was actually intriguing and enjoyable. We had the opportunity to sequence our DNA and even dissect a rat! I had a lot of fun in this class, and the quizzes/final were definitely not difficult and required just a few hours of study. I definitely recommend this class, and hopefully you get a helpful TA because they are basically the ones giving you your final grade.
* This class is not curved. Grades may be normalized if there are discrepancies in scores among different lab sections, but this rarely happens*