Description: Lecture, three hours; discussion, one hour. Requisite: course 111B. Discussion of cellular and molecular players involved in cardiac morphogenesis, postnatal heart growth, and cardiac regeneration, to better understand emergence of cardiac diseases such as congenital heart disease, coronary artery disease, and atherosclerosis. Use of primary literature to highlight modern genetic tools such as transgenic animal models and sequencing technologies to investigate how various cardiac cell lineages and/or gene perturbations contribute to cardiac pathophysiology such as cardiomyocyte death, cardiac fibrosis, and vascular dysfunction. Letter grading.

Units: 4.0