Description: Lecture, two hours. Graduate- and postgraduate-level course that covers broad range of topics in both basic and clinical aspects of developmental hematology. Pediatric hematologic disorders provide important paradigm to study other developmental systems. Subjects include hematopoiesis, basic stem cell biology, angiogenesis, alternative models to study developmental hematology (zebrafish and "Drosophila"), basic physiology of normal and abnormal red cells, platelets, and white cells, leukemogenesis and novel therapeutics to treat leukemia, basic and clinical stem cell transplantation, state-of-the-art methods in developmental hematology (genomics, proteomics, and gene therapy, design of clinical trials, and biomathematical modeling and statistics in developmental hematology. Letter grading.

Units: 4.0