Description: Lecture, one hour; discussion, one hour. Preparation: introductory biostatistics and epidemiology courses. Requisite: course 254. Intended primarily for doctoral students interested in doing epidemiologic research. Methodological aspects of research in nutritional epidemiology. Topics include why and how to conduct validation studies, adjustment for energy intake, correction of measurement error. Methods related to genetic polymorphism, biochemical markers, gene-nutrient interaction in chronic diseases. Theoretical as well as practical aspects. S/U or letter grading.

Units: 2.0