Description: (Same as Bioengineering M182.) Lecture, three hours; discussion, one hour; laboratory, two hours; outside study, six hours. Requisite: Mathematics 3B, 31B, or Life Sciences 30A. Recommended corequisite: Mathematics 3C, 32A, or Life Sciences 30B. Designed for undergraduate students in life sciences and engineering. Introduction to explicit modeling and simulation of dynamic biological systems. Presentation of how biology, biochemistry, and physiology underlying dynamic systems biomodeling are transformed into system diagrams and graphs for refining conceptual understanding of their form and function. Structural models, formulated from basic conservation and mass action laws and feedback concepts, are further transformed into first-order differential equations, and implemented in simulation diagrams for quantifying and exploring biosystem properties. Examples show how to use these explicit models to gain clarity on nature of biosystem phenomena, and frame questions and explore new ideas for research. Letter grading.

Units: 4.0